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Metronidazole has revealed evidence of mutagenic exercise in various in vitro bacterial assay programs. In addition, a dose-similar increase in the frequency of micronuclei was noticed in mice following intraperitoneal injections. A rise in chromosomal aberrations in peripheral blood lymphocytes was reported in patients with Crohn’s sickness who were addressed with two hundred to 1200 mg/day of metronidazole for 1 to 24 months.
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